MAPK1 Antibody

• Background:

  Mitogen-activated protein kinase 1; extracellular signal-regulated kinase 2; protein tyrosine kinase ERK2; mitogen-activated protein kinase 2. This protein is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

• NCBI Gene ID:

  5594

• Swiss Prot:

  P28482

• Accession Number:

  NP_620407.1

• Host:

  Chicken

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  232-360

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction, Cancer

• Purification:

  Antigen affinity-purified

• Concentration:

  1 mg/mL

• Buffer:

  Phosphate-Buffered Saline. No preservatives added.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  MAPK1 antibody can be stored at 4˚ C for short term (weeks) . Long term storage should be at -20˚ C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  41.3 kDa (calculated)

• Applications Notes:

  ERK2 antibody can be used for the detection of ERK2 by Western blot, may also work for IHC and ICC.

• Symbol:

  MAPK1

• NCBI Official Name:

  Mitogen-activated protein kinase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bhalla, U. S., Ram, P. T., Iyengar, R. MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297: 1018-1023, 2002.

• Other Product Names:

  ERK2, PRKM1, PRKM2, Mitogen-activated protein kinase 1, ERT1, MAP kinase 1, ERK, p38, p40, p41, ERK2, ERK-2, MAPK2, P42MAPK, p41mapk, p42-MAPK

• Tested Applications:

  WB

• Protein ID:

  20986531

• Physical Properties:

  Liquid