MAP4K3 Antibody

CAT: 0223-64-153Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-64-153Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MAP4K3 encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1) . This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) .
NCBI Gene ID
8491
Swiss Prot
Q8IVH8
Accession Number
Q8IVH8
Host
Rabbit
Reactivity
Human
Immunogen
This MAP4K3 antibody is generated from rabbits immunized with a recombinant protein of human MAP4K3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
101 kDa
Fragment
Rabbit Ig
Symbol
MAP4K3
NCBI Official Name
Mitogen-activated protein kinase kinase kinase kinase 3
NCBI Organism
Homo sapiens
Background Reference 01
Yan, L., et al. Mol. Cell 37 (5) :633-642 (2010)
Background Reference 02
Ichikawa, S., et al. J. Bone Miner. Res. (2010) In press :
Background Reference 03
Lam, D., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (29) :11978-11983 (2009)
Background Reference 04
Wu, C., et al. Proteomics 7 (11) :1775-1785 (2007)
Other Product Names
Mitogen-activated protein kinase kinase kinase kinase 3, Germinal center kinase-related protein kinase, GLK, MAPK/ERK kinase kinase kinase 3, MEK kinase kinase 3, MEKKK 3, MAP4K3, RAB8IPL1
Tested Applications
WB, IHC-P, Flow
Protein ID
29427817
Physical Properties
Liquid

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