MAP4K3 Antibody

• Background:

  MAP4K3 encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1) . This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) .

• NCBI Gene ID:

  8491

• Swiss Prot:

  Q8IVH8

• Accession Number:

  Q8IVH8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MAP4K3 antibody is generated from rabbits immunized with a recombinant protein of human MAP4K3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  101 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MAP4K3

• NCBI Official Name:

  Mitogen-activated protein kinase kinase kinase kinase 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yan, L., et al. Mol. Cell 37 (5) :633-642 (2010)

• Background Reference 02:

  Ichikawa, S., et al. J. Bone Miner. Res. (2010) In press :

• Background Reference 03:

  Lam, D., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (29) :11978-11983 (2009)

• Background Reference 04:

  Wu, C., et al. Proteomics 7 (11) :1775-1785 (2007)

• Other Product Names:

  Mitogen-activated protein kinase kinase kinase kinase 3, Germinal center kinase-related protein kinase, GLK, MAPK/ERK kinase kinase kinase 3, MEK kinase kinase 3, MEKKK 3, MAP4K3, RAB8IPL1

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  29427817

• Physical Properties:

  Liquid