MAP4K2 Antibody

• Background :

  The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.

• NCBI Gene ID :

  5871

• Swiss Prot :

  Q12851

• Accession Number :

  Q12851

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This MAP4K2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 321-349 amino acids from the Central region of human MAP4K2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  92 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  MAP4K2

• NCBI Official Name :

  Mitogen-activated protein kinase kinase kinase kinase 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Bailey, S.D., et al. Diabetes Care (2010) In press :

• Background Reference 02 :

  Fidalgo, M., et al. J. Cell. Sci. 123 (PT 8), 1274-1284 (2010) :

• Background Reference 03 :

  Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

• Background Reference 04 :

  Wissing, J., et al. Mol. Cell Proteomics 6 (3) :537-547 (2007)

• Other Product Names :

  Mitogen-activated protein kinase kinase kinase kinase 2, B lymphocyte serine/threonine-protein kinase, Germinal center kinase, GC kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, MEKKK 2, Rab8-interacting protein, MAP4K2, GCK, RAB8IP

• Tested Applications :

  WB, Flow

• Protein ID :

  215274019

• Physical Properties :

  Liquid