MAP4K2 Antibody

• Background :

  MAP4K2 is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.

• NCBI Gene ID :

  5871

• Swiss Prot :

  Q12851

• Accession Number :

  NP_004570

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MAP4K2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction, Immunology

• Purification :

  Antibody is purified by peptide affinity chromatography method.

• Positive Control :

  Cat. No. XBL-10409 - Fetal Liver Tissue Lysate

• Concentration :

  Batch dependent

• Buffer :

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store MAP4K2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight :

  91 kDa

• Applications Notes :

  MAP4K2 antibody can be used for detection of MAP4K2 by ELISA at 1:312500. MAP4K2 antibody can be used for detection of MAP4K2 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol :

  MAP4K2

• NCBI Official Name :

  Mitogen-activated protein kinase kinase kinase kinase 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Wissing, J., (2007) Mol. Cell Proteomics 6 (3), 537-547.

• Other Product Names :

  MAP4K2, BL44, GCK, RAB8IP

• Tested Applications :

  ELISA, WB

• Protein ID :

  22035600

• Physical Properties :

  Liquid