TrkA Antibody

• Background:

  TRKA (also known as NTRK1) is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in the TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.

• NCBI Gene ID:

  4914

• Swiss Prot:

  P04629

• Accession Number:

  P04629

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This TrkA antibody is generated from rabbits immunized with TrkA his fusion protein

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  87 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  NTRK1

• NCBI Official Name:

  High affinity nerve growth factor receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Tokusashi, Y., et al., Int. J. Cancer 114 (1) :39-45 (2005) .

• Background Reference 02:

  Schulte, J.H., et al., Oncogene 24 (1) :165-177 (2005) .

• Background Reference 03:

  Frattini, M., et al., Oncogene 23 (44) :7436-7440 (2004) .

• Background Reference 04:

  Tacconelli, A., et al., Cancer Cell 6 (4) :347-360 (2004) .

• Other Product Names:

  High affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, Trk-A, gp140trk, p140-TrkA, NTRK1, MTC, TRK, TRKA

• Tested Applications:

  WB, IF, Flow

• Protein ID:

  94730402

• Physical Properties:

  Liquid