TrkC Antibody

• Background:

  TRKC, a member of the insuline receptor subfamily of Tyr protein kinases, is a receptor for neurotrophin-3 (NT-3) . Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.

• NCBI Gene ID:

  4916

• Swiss Prot:

  Q16288

• Accession Number:

  Q16288

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TrkC antibody is generated from rabbits immunized with a his tag recombinant protein of human TrkC.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  94 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  NTRK3

• NCBI Official Name:

  NT-3 growth factor receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  McGregor, L.M., et al., Genomics 22 (2) :267-272 (1994) .

• Background Reference 02:

  Shelton, D.L., et al., J. Neurosci. 15 (1 Pt 2), 477-491 (1995) .

• Other Product Names:

  NT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, NTRK3, TRKC

• Tested Applications:

  WB, IHC-P

• Protein ID:

  134035335

• Physical Properties:

  Liquid