TrkA (phospho Ser791) Antibody

• Background:

  Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF) . Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC γ1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC γ1-dependent signaling pathway.

• NCBI Gene ID:

  4914

• Swiss Prot:

  P04629

• Accession Number:

  NP_001007793.1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  TrkA (Phospho-Ser791) antibody was raised against a peptide sequence around phosphorylation site of tyrosine791 (P-V-Y (p) -L-D) derived from Human TrkA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific, Neuroscience

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  140 kDa

• Specificity:

  This antibody detects endogenous level of TrkA only when phosphorylated at tyrosine 791.

• Applications Notes:

  Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

• Symbol:

  NTRK1

• NCBI Official Name:

  Neurotrophic tyrosine kinase, receptor, type 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23; 104 (43) : 17210-5. Valdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104 (30) : 12270-5Inoue K, et al. J Biol Chem. 2007 Aug 17;282 (33) : 24175-84

• Other Product Names:

  MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, MGF, SCF, High affinity nerve growth factor receptor precursor, NTRK1, Slow nerve growth factor receptor, TRK1 transforming tyrosine kinase protein

• Tested Applications:

  WB, IF

• Protein ID:

  56118210

• Physical Properties:

  Liquid