TrkB (phospho Tyr705) Antibody

• Background:

  Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF) . Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC γ1.

• NCBI Gene ID:

  4915

• Swiss Prot:

  Q16620

• Accession Number:

  NP_001007098.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  TrkB (Phospho-Tyr705) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 705 (T-D-Y P-Y-R) derived from Human TrkB.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific, Neuroscience

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  140 kDa

• Specificity:

  This antibody detects endogenous level of TrkB only when phosphorylated at tyrosine 705.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  NTRK2

• NCBI Official Name:

  Neurotrophic tyrosine kinase, receptor, type 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Woronowicz A, et al. Glycobiology. 2007 Jan;17 (1) : 10-24. Mojsilovic-Petrovic J, et al. J Neurosci. 2006 Sep 6;26 (36) : 9250-63. Lewis MA, et al. Mol Pharmacol. 2006 Apr;69 (4) : 1396-404. Cai D, et al. Physiol Genomics. 2006 Feb 14;24 (3) : 191-7.

• Other Product Names:

  TRKB, trk-B, GP145-TrkB, P53, BDNF/NT-3 growth factors receptor precursor, EC 2.7.10.1, GP145-TrkB/GP95-TrkB, NTRK2

• Tested Applications:

  WB

• Protein ID:

  55956790

• Physical Properties:

  Liquid