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PDGFRA Antibody

CAT: 0223-63-116Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-116Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
NCBI Gene ID
5156
Swiss Prot
P16234
Accession Number
P16234
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PDGFRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1048-1077 amino acids from the C-terminal region of human PDGFRA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
123 kDa
Fragment
Rabbit Ig
Symbol
PDGFRA
NCBI Official Name
Platelet-derived growth factor receptor alpha
NCBI Organism
Homo sapiens
Background Reference 01
Cools, J., et al., N. Engl. J. Med. 348 (13) :1201-1214 (2003) .
Background Reference 02
Heinrich, M.C., et al., Science 299 (5607) :708-710 (2003) .
Background Reference 03
Andrae, J., et al., Biochem. Biophys. Res. Commun. 296 (3) :604-611 (2002) .
Background Reference 04
Ribom, D., et al., J. Neurol. Neurosurg. Psychiatr. 72 (6) :782-787 (2002) .
Other Product Names
Platelet-derived growth factor receptor alpha, PDGF-R-alpha, PDGFR-alpha, Alpha platelet-derived growth factor receptor, Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140a antigen, Platelet-derived growth factor alpha receptor, Platelet-derived growth factor receptor 2, PDGFR-2, CD140a, PDGFRA, PDGFR2, RHEPDGFRA
Tested Applications
WB, IHC-P, Flow
Protein ID
129892
Physical Properties
Liquid

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