PDGF R alpha / PDGFRA Recombinant Protein

• Background:

  PDGFRA (platelet-derived growth factor receptor A), also termed PDGFRα (platelet-derived growth factor receptor α), is a receptor located on the surface of a wide range of cell types. This receptor binds to certain isoforms of platelet-derived growth factors (PDGFs) and thereby becomes active in stimulating cell signaling pathways that elicit responses such as cellular growth and differentiation. The receptor is critical for the development of certain tissues and organs during embryogenesis and for the maintenance of these tissues and organs, particularly hematologic tissues, throughout life. Mutations in the gene which codes for PDGFRA, are associated with an array of clinically significant neoplasms.

• NCBI Gene ID:

  5156

• Swiss Prot:

  P16234

• Accession Number:

  NP_006197.1

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  58.4 kDa

• Applications Notes:

  This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 58.4 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  Platelet derived growth factor receptor alpha

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Matsui T, et al. 1989. Proc Natl Acad Sci U S A. 86 (21) :8314-8.

• Background Reference 02:

  Kelly JD, et al. 1991. J Biol Chem. 266 (14) :8987-92.

• Background Reference 03:

  Koschmann C, et al. 2016. Oncotarget. 7 (40) :65696-65706.

• Other Product Names:

  PDGFRA, CD140A, PDGFR2, RHEPDGFRA, MGC74795

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3