PDGFA Antibody

• Background:

  PDGFA is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth.

• NCBI Gene ID:

  5154

• Swiss Prot:

  P04085

• Accession Number:

  P04085

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PDGFA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-89 amino acids from the N-terminal region of human PDGFA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Cell Cycle, Immunology, Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  24 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PDGFA

• NCBI Official Name:

  Platelet-derived growth factor subunit A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Monje, P., et al., Mol. Cell. Biol. 23 (19) :7030-7043 (2003) . Gianni, D., et al., J. Biol. Chem. 278 (11) :9290-9297 (2003) . Muller, C., et al., J. Biol. Chem. 278 (20) :18330-18335 (2003) . Chui, C.M., et al., Cytokine 21 (2) :51-64 (2003) . Laprise, M.H., et al., Blood 100 (10) :3578-3587 (2002) .

• Other Product Names:

  Platelet-derived growth factor subunit A, PDGF subunit A, PDGF-1, Platelet-derived growth factor A chain, Platelet-derived growth factor alpha polypeptide, PDGFA, PDGF1

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid