PDGFRL Antibody

• Background:

  This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor.

• NCBI Gene ID:

  5157

• Swiss Prot:

  Q15198

• Accession Number:

  Q15198

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This PDGFRL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-44 amino acids from the N-terminal region of human PDGFRL.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Monkey

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  42 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PDGFRL

• NCBI Official Name:

  Platelet-derived growth factor receptor-like protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

• Background Reference 02:

  Guo, F.J., et al. World J. Gastroenterol. 16 (12) :1465-1472 (2010)

• Background Reference 03:

  Riker, A.I., et al. BMC Med Genomics 1, 13 (2008) :

• Background Reference 04:

  Xu, M., et al. BMC GenomicsSUPPL 1, S12 (2008) :

• Other Product Names:

  Platelet-derived growth factor receptor-like protein, PDGFR-like protein, PDGF receptor beta-like tumor suppressor, PDGFRL, PRLTS

• Tested Applications:

  WB

• Protein ID:

  74762141

• Physical Properties:

  Liquid