PDK4 Antibody

• Background:

  PDK4 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.

• NCBI Gene ID:

  5166

• Swiss Prot:

  Q16654

• Accession Number:

  Q16654

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PDK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-111 amino acids from the Central region of human PDK4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  46 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PDK4

• NCBI Official Name:

  [Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 4, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rosa, G., et al., Obes. Res. 11 (2) :176-182 (2003) .

• Background Reference 02:

  Razeghi, P., et al., Cardiology 97 (4) :203-209 (2002) .

• Background Reference 03:

  Rowles, J., et al., J. Biol. Chem. 271 (37) :22376-22382 (1996) .

• Background Reference 04:

  Gudi, R., et al., J. Biol. Chem. 270 (48) :28989-28994 (1995) .

• Other Product Names:

  [Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 4, mitochondrial, Pyruvate dehydrogenase kinase isoform 4, PDK4, PDHK4

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  3183120

• Physical Properties:

  Liquid