PDK2 Antibody

• Background:

  PDK2 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.

• NCBI Gene ID:

  5164

• Swiss Prot:

  Q15119

• Accession Number:

  Q15119

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PDK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 378-407 amino acids from the C-terminal region of human PDK2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat, Monkey

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  46 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PDK2

• NCBI Official Name:

  [Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 2, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hiromasa, Y., et al., J. Biol. Chem. 278 (36) :33681-33693 (2003) . Baker, J.C., et al., J. Biol. Chem. 275 (21) :15773-15781 (2000) . Gudi, R., et al., J. Biol. Chem. 270 (48) :28989-28994 (1995) . Sun, W. et al. Clin Cancer Res. January 15; 15 (2) : 476?84 (2009) .

• Other Product Names:

  [Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 2, mitochondrial, Pyruvate dehydrogenase kinase isoform 2, PDH kinase 2, PDKII, PDK2, PDHK2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  21431820

• Physical Properties:

  Liquid