COL6A1 Antibody

• Background:

  The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1 (VI), alpha2 (VI), and alpha3 (VI) chains. The protein COL6A1 is the alpha 1 subunit of type VI collagen (alpha1 (VI) chain) . Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy.

• NCBI Gene ID:

  1291

• Swiss Prot:

  P12109

• Accession Number:

  P12109

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This COL6A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 831-858 amino acids from the C-terminal region of human COL6A1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  109 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  COL6A1

• NCBI Official Name:

  Collagen alpha-1 (VI) chain

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Martoni, E., Hum. Mutat. 30 (5), E662-E672 (2009)

• Background Reference 02:

  Kim, T.H., J. Rheumatol. 35 (9), 1849-1852 (2008)

• Background Reference 03:

  Fujita, A., Genet. Mol. Res. (2), 371-378 (2008)

• Other Product Names:

  Collagen alpha-1 (VI) chain, COL6A1

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  125987811

• Physical Properties:

  Liquid