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COL9A1 Antibody

CAT: 0223-61-492Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-492Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
COL9A1 is one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Mutations in the COL9A1 gene are associated with osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a form of chondrodysplasia, and with Stickler syndrome, a disease characterized by ophthalmic, orofacial, articular, and auditory defects.
NCBI Gene ID
1297
Swiss Prot
P20849
Accession Number
P20849
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
This COL9A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 428-456 amino acids from the Central region of human COL9A1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
92 kDa
Fragment
Rabbit Ig
Symbol
COL9A1
NCBI Official Name
Collagen alpha-1 (IX) chain
NCBI Organism
Homo sapiens
Background Reference 01
Fresquet, M., J. Biol. Chem. 282 (48), 34634-34643 (2007)
Background Reference 02
Liu, L.Y., Yi Chuan 29 (4), 427-432 (2007)
Background Reference 03
Van Camp, G., Am. J. Hum. Genet. 79 (3), 449-457 (2006)
Background Reference 04
Sivakumaran, T.A., J. Assoc. Res. Otolaryngol. (2), 160-172 (2006)
Other Product Names
Collagen alpha-1 (IX) chain, COL9A1
Tested Applications
WB, IHC-P
Protein ID
296439373
Physical Properties
Liquid

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