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COL1A1 Antibody

CAT: 0223-15-039Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-15-039Size:100 µL
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Background
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
NCBI Gene ID
1277
Swiss Prot
P02452
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human COL1A1 (NP_000079.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity purification
Positive Control
Mouse spleen
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 139kDa
Fragment
IgG
Symbol
COL1A1
Positive Control 2
Mouse kidney
Positive Control 3
Rat liver
Positive Control 4
Rat lung
NCBI Official Name
Collagen, type I, alpha 1
NCBI Organism
Homo sapiens
Other Product Names
Alpha-1 type I collagenOI4
Tested Applications
WB, IHC, IF
Physical Properties
Liquid

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