COL1A1 Antibody

• Background:

  This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

• NCBI Gene ID:

  1277

• Swiss Prot:

  P02452

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to a sequence within amino acids 100-200 of human COL1A1 (NP_000079.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  Mouse spleen

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 139kDa

• Fragment:

  IgG

• Symbol:

  COL1A1

• Positive Control 2:

  Mouse kidney

• Positive Control 3:

  Rat liver

• Positive Control 4:

  Rat lung

• NCBI Official Name:

  Collagen, type I, alpha 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Alpha-1 type I collagenOI4

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid