COL1A1 Antibody

CAT: 0223-57-762Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-762Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish].
NCBI Gene ID
1277
Swiss Prot
P02452
Accession Number
P02452
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This COL1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1077-1106 amino acids from the C-terminal region of human COL1A1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
139 kDa
Fragment
Rabbit Ig
Symbol
COL1A1
NCBI Official Name
Collagen alpha-1 (I) chain
NCBI Organism
Homo sapiens
Background Reference 01
Blades, H.Z., et al. Bone 47 (5) :989-994 (2010) Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) Jin, H., et al. Osteoporos Int (2010) In pressSzczesny, G., et al. Arch Orthop Trauma Surg (2010) In pressCheung, M.S., et al. J. Bone Miner. Res. (2010) In press :
Other Product Names
Collagen alpha-1 (I) chain, Alpha-1 type I collagen, COL1A1
Tested Applications
WB, IHC-P
Protein ID
296439504
Physical Properties
Liquid

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