COL1A1 Antibody

• Background:

  This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish].

• NCBI Gene ID:

  1277

• Swiss Prot:

  P02452

• Accession Number:

  P02452

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This COL1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1077-1106 amino acids from the C-terminal region of human COL1A1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  139 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  COL1A1

• NCBI Official Name:

  Collagen alpha-1 (I) chain

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Blades, H.Z., et al. Bone 47 (5) :989-994 (2010) Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) Jin, H., et al. Osteoporos Int (2010) In pressSzczesny, G., et al. Arch Orthop Trauma Surg (2010) In pressCheung, M.S., et al. J. Bone Miner. Res. (2010) In press :

• Other Product Names:

  Collagen alpha-1 (I) chain, Alpha-1 type I collagen, COL1A1

• Tested Applications:

  WB, IHC-P

• Protein ID:

  296439504

• Physical Properties:

  Liquid