GRB2 Antibody

• Background:

  GRB2 binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences.

• NCBI Gene ID:

  2885

• Swiss Prot:

  P62993

• Accession Number:

  P62993

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GRB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-118 amino acids from the Central region of human GRB2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Xenopus, Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  25 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GRB2

• NCBI Official Name:

  Growth factor receptor-bound protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kondo, A., J. Biol. Chem. 283 (3), 1428-1436 (2008)

• Background Reference 02:

  Morimatsu, M., Proc. Natl. Acad. Sci. U.S.A. 104 (46), 18013-18018 (2007)

• Background Reference 03:

  Martinez, N., Cell. Signal. 19 (11), 2277-2285 (2007)

• Other Product Names:

  Growth factor receptor-bound protein 2, Adapter protein GRB2, Protein Ash, SH2/SH3 adapter GRB2, GRB2, ASH

• Tested Applications:

  WB, IHC-P

• Protein ID:

  51702266

• Physical Properties:

  Liquid