GRB7 Antibody

• Background:

  GRB7 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK) .

• NCBI Gene ID:

  2886

• Swiss Prot:

  Q14451

• Accession Number:

  Q14451

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GRB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 289-318 amino acids from the Central region of human GRB7.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  60 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  GRB7

• NCBI Official Name:

  Growth factor receptor-bound protein 7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Depetris, R.S., et al. Nat. Struct. Mol. Biol. 16 (8) :833-839 (2009)

• Background Reference 02:

  Chu, P.Y., et al. J. Biol. Chem. 284 (30) :20215-20226 (2009)

• Background Reference 03:

  Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18 (1) :255-259 (2009)

• Background Reference 04:

  Bai, T., et al. Carcinogenesis 29 (3) :473-479 (2008)

• Other Product Names:

  Growth factor receptor-bound protein 7, B47, Epidermal growth factor receptor GRB-7, GRB7 adapter protein, GRB7

• Tested Applications:

  WB

• Protein ID:

  116242503

• Physical Properties:

  Liquid