GRB2 (phospho Ser159) Antibody

CAT: 0223-79-882Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-79-882Size:0.1 mg
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Background
This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
NCBI Gene ID
9846
Swiss Prot
Q9UQC2
Accession Number
NP_536739.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
GRB2 (phospho Ser159) antibody was raised against a peptide sequence around phosphorylation site of Serine 159 (K-S-S (p) -A-P) derived from Human GRB2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
100 kDa
Fragment
IgG
Specificity
The antibody detects endogenous levels of GRB2 only when phosphorylated at serine 159.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
GAB2
NCBI Official Name
GRB2-associated binding protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Nishida K., Blood 93:1809-1816 (1999) .
Background Reference 02
Nagase T., DNA Res. 5:31-39 (1998) .
Background Reference 03
Taylor T.D., Nature 440:497-500 (2006) .
Other Product Names
GABJ, KIAA0571, pp100
Tested Applications
WB
Protein ID
18105042
Physical Properties
Liquid

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