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GRB2 Recombinant Protein

CAT: 0223-92-001Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-92-001Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
As an adaptor protein, Growth Factor Receptor-Bound Protein 2 (GRB2) is involved in siganl transduction and consists of a central SH2 domain flanked by two SH3 domains. GRB2 associates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain, stimulating GTP binding to Ras, which in turn activates MAPK and other signaling pathway.It also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK. probably via the concerted action of both its SH2 and SH3 domains.
CAS Number
9000-83-3
NCBI Gene ID
2885
Swiss Prot
P62993
Accession Number
P62993
Tag
C-6 His tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Signal Transduction, Other
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
26.3 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Growth factor receptor bound protein 2
NCBI Organism
Homo sapiens
Other Product Names
Growth Factor Receptor-Bound Protein 2, Adapter Protein GRB2, Protein Ash, SH2/SH3 Adapter GRB2, GRB2, ASH
Species
Human
Physical Properties
Lyophilized

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