CD105 Antibody

• Background:

  CD105 is a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in its gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia.

• NCBI Gene ID:

  2022

• Swiss Prot:

  P17813

• Accession Number:

  P17813

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This CD105 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-409 amino acids from the Central region of human CD105.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  71 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ENG

• NCBI Official Name:

  Endoglin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chen, Y., Ann. Neurol. 66 (1), 19-27 (2009)

• Background Reference 02:

  Rius, C., Blood 92 (12), 4677-4690 (1998)

• Other Product Names:

  Endoglin, CD105, ENG, END

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  3041681

• Physical Properties:

  Liquid