CCR5 (CD195) Antibody

• Background:

  Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

• NCBI Gene ID:

  1234

• Swiss Prot:

  P51681

• Accession Number:

  NP_000570.1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  CCR5 (CD195) antibody was raised against a peptide sequence around aa.11~15 (D-I-N-Y-Y) derived from Human CCR5 (CD195) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  41 kDa

• Specificity:

  This antibody detects endogenous level of total CCR5 (CD195) protein.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  CCR5

• NCBI Official Name:

  Chemokine (C-C motif) receptor 5 (gene/pseudogene)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Samson M., Labbe O., Mollereau C., Vassart G., Parmentier M. Biochemistry 35:3362-3367 (1996) Raport C. J., Gosling J., Schweichart V. L., Gray P. W., Charo I. F. J. Biol. Chem. 271:17161-17166 (1996) Combadiere C., Ahuja S. K., Tiffany H. L., Murphy P. M. J. Leukoc. Biol. 60:147-152 (1996)

• Other Product Names:

  CKR5, CCR-5, CD195, CKR-5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5, CREB2, CREBP1, CKR5

• Tested Applications:

  WB

• Protein ID:

  4502639

• Physical Properties:

  Liquid