CD103 Antibody [2E7]

• Background:

  CD103 is a member of the integrin series of adhesion molecules. This antigen defines a developmentally important subset of T cells, namely mucosal T cells including all IEL (intraepithelial lymphocytes) and ~20% of lamina propria T cells. Expression of CD103 is more restricted outside these mucosal organs appearing at lower levels on T cell subsets of the lymph node, dendritic epidermis, and periphery. In non-epithelial CD103+ T cells there is a bias toward expression on CD8+ cells. The 2E7 monoclonal antibody exhibits antigen immunoprecipitation patterns similar if not identical to the rat anti-mouse CD103 monoclonal antibody M290. 2E7 is reported to have signal-inducing activity in a redirected lysis assay and to costimulate IEL and CD8+ lymph node cells in conjunction with anti-TCR in vitro which runs counter to the usual inhibition of CTL by anti-integrins. This costimulatory activity is also shared by the monoclonal antibody M290. The property of costimulation is not unique to the mouse since the combination of anti-human alphaIEL plus anti-TCR will produce similar proliferation in human cells with the exception that CD8+ cells are not stimulated.

• NCBI Gene ID:

  16407

• Swiss Prot:

  Q60677

• Accession Number:

  Q60677

• Host:

  Hamster

• Reactivity:

  Mouse

• Immunogen:

  C57BL/6J mouse intestinal intraepithelial lymphocytes (IEL)

• Clonality:

  Monoclonal

• Clone:

  [2E7]

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Stem Cell, Signal Transduction

• Concentration:

  0.5 mg/mL

• Buffer:

  Supplied in PBS

• Modification:

  None

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  Store vial at -20˚ C

• Fragment:

  IgG

• Specificity:

  CD103

• Applications Notes:

  CD103 Antibody [2E7] for use in flow cytometry, immunohistochemistry, immunoprecipitation, and activation assays.

• Symbol:

  Itgae

• NCBI Official Name:

  Integrin alpha E, epithelial-associated

• NCBI Organism:

  Mus musculus

• Other Product Names:

  Integrin alphaIEL, alphaE integrin, ITGAE

• Tested Applications:

  WB, IHC-Fr, ICC, Flow, IP

• Physical Properties:

  Liquid