CD115 Antibody [AFS98]

• Background:

  The AFS98 monoclonal antibody specifically reacts with the mouse CD115 molecule, a 150 kDa receptor for the colony stimulating factor (CSF-1) or macrophage CFS (M-CFS), expressed by some epithelial cells, monocytes, osteoclasts, and macrophages. The colony stimulating factor-1 regulates the proliferation and the differentiation of the monocytic lineage cells. The AFS98 antibody can be used to identify myeloid lineage cells.

• NCBI Gene ID:

  12978

• Swiss Prot:

  P09581

• Host:

  Rat

• Reactivity:

  Mouse

• Clonality:

  Monoclonal

• Clone:

  AFS98

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Innate Immunity

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C . Do not freeze.

• Fragment:

  Rat IgG2a, kappa

• Specificity:

  The AFS98 monoclonal antibody specifically reacts with the mouse CD115 molecule, a 150 kDa receptor for the colony stimulating factor (CSF-1) or macrophage CFS (M-CFS), expressed by some epithelial cells, monocytes, osteoclasts, and macrophages.

• Symbol:

  Csf1r

• NCBI Official Name:

  Colony stimulating factor 1 receptor

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Murayama, T., Yokode, M., Kataoka, H., Imabayashi, T., Yoshida, H., Sano, H., ... Kita, T. (1999) . Intraperitoneal administration of antic-fms monoclonal antibody prevents initial events of atherogenesis but does not reduce the size of advanced lesions in apolipoprotein Edeficient mice.Circulation,99 (13), 1740-1746.

• Background Reference 02:

  Sudo, T., Nishikawa, S., Ogawa, M., Kataoka, H., Ohno, N., Izawa, A., Hayashi, S. (1995) . Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M.Oncogene,11 (12), 2469-2476.

• Background Reference 03:

  Yoshino, M., Yamazaki, H., Yoshida, H., Niida, S., Nishikawa, S. I., Ryoke, K., ... Hayashi, S. I. (2003) . Reduction of osteoclasts in a critical embryonic period is essential for inhibition of mouse tooth eruption.Journal of Bone and Mineral Research,18 (1), 108-116.

• Other Product Names:

  Fms, CD115, Csfmr, Fim-2, CSF-1R, M-CSFR, M-CSF-R, AI323359, Csf1r

• Tested Applications:

  Flow, Functional Assays, WB

• Physical Properties:

  Liquid