CD103 Antibody [2E7]

CAT: 0223-98-974Size: 0.5 mgDry Ice: NoHazardous: No
CAT#:0223-98-974Size:0.5 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD103 is a member of the integrin series of adhesion molecules. This antigen defines a developmentally important subset of T cells, namely mucosal T cells including all IEL (intraepithelial lymphocytes) and ~20% of lamina propria T cells. Expression of CD103 is more restricted outside these mucosal organs appearing at lower levels on T cell subsets of the lymph node, dendritic epidermis, and periphery. In non-epithelial CD103+ T cells there is a bias toward expression on CD8+ cells. The 2E7 monoclonal antibody exhibits antigen immunoprecipitation patterns similar if not identical to the rat anti-mouse CD103 monoclonal antibody M290. 2E7 is reported to have signal-inducing activity in a redirected lysis assay and to costimulate IEL and CD8+ lymph node cells in conjunction with anti-TCR in vitro which runs counter to the usual inhibition of CTL by anti-integrins. This costimulatory activity is also shared by the monoclonal antibody M290. The property of costimulation is not unique to the mouse since the combination of anti-human alphaIEL plus anti-TCR will produce similar proliferation in human cells with the exception that CD8+ cells are not stimulated.
NCBI Gene ID
16407
Swiss Prot
Q60677
Accession Number
Q60677
Host
Hamster
Reactivity
Mouse
Immunogen
C57BL/6J mouse intestinal intraepithelial lymphocytes (IEL)
Clonality
Monoclonal
Clone
[2E7]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Stem Cell, Signal Transduction
Concentration
0.5 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG
Specificity
CD103
Applications Notes
CD103 Antibody [2E7] for use in flow cytometry, immunohistochemistry, immunoprecipitation, and activation assays.
Symbol
Itgae
NCBI Official Name
Integrin alpha E, epithelial-associated
NCBI Organism
Mus musculus
Other Product Names
Integrin alphaIEL, alphaE integrin, ITGAE
Tested Applications
Flow
Physical Properties
Liquid

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