Mouse Txnip Antibody

• Background:

  May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.

• NCBI Gene ID:

  56338

• Swiss Prot:

  Q8BG60

• Accession Number:

  Q8BG60

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This Mouse Txnip antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the Central region of mouse Txnip.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  44 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  Txnip

• NCBI Official Name:

  Thioredoxin-interacting protein

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Kwon, H.J., et al. Toxicol. Appl. Pharmacol. 248 (3) :277-284 (2010)

• Background Reference 02:

  Kwon, H.J., et al. J. Immunol. 185 (7) :3980-3989 (2010)

• Background Reference 03:

  Ren, Y., et al. FEBS Lett. 584 (15) :3480-3485 (2010)

• Background Reference 04:

  Chutkow, W.A., et al. Diabetes 59 (6) :1424-1434 (2010)

• Other Product Names:

  Thioredoxin-interacting protein, Vitamin D3 up-regulated protein 1, Txnip, Vdup1

• Tested Applications:

  WB

• Physical Properties:

  Liquid