Mouse Txnip Antibody (Center) [APR31914G]

• Background:

  Tissue Location: Ubiquitously expressed.

• Synonyms:

  Thioredoxin-interacting protein, Vitamin D3 up-regulated protein 1, Txnip, Vdup1

• Gene Name:

  Txnip

• Gene ID:

  56338

• UniProt:

  Q8BG60

• Chromosomal Location:

  Cytoplasm.

• Applications:

  IHC-P, WB

• Dilution:

  IHC-P--1:100 WB--1:2000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity) . Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.

• Molecular Weight:

  44363

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mouse Txnip Antibody (Center) [APR31914G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=56338

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8BG60