Mouse Dnmt3L Antibody

• Background:

  MDnmt3L (DNA methyltransferase 3L) does not appear to be catalytically active due to loss of the critical active site residues. It may function not directly as a DNA methyltransferase but rather as a regulator of methylation at imprinted loci. It is required specifically for the establishment of genomic imprints but is dispensable for their propagation. It is essential for the de novo methylation of single-copy DNA sequences. The protein is well-express in testis, thymus, ovary, and heart. mDnmt3L, which belongs to the 5-cytosine methyltransferase family, contains 1 ADD-type zinc finger.

• NCBI Gene ID:

  54427

• Swiss Prot:

  Q9CWR8

• Accession Number:

  Q9CWR8

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This Mouse Dnmt3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-421 amino acids from mouse Dnmt3L.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  Dnmt3l

• NCBI Official Name:

  DNA (cytosine-5) -methyltransferase 3-like

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Okazaki, Y., et al., Nature 420 (6915) :563-573 (2002) .

• Background Reference 02:

  Bourc'his, D., et al., Science 294 (5551) :2536-2539 (2001) .

• Background Reference 03:

  Aapola, U., et al., Cytogenet. Cell Genet. 92 (1-2), 122-126 (2001) .

• Other Product Names:

  DNA (cytosine-5) -methyltransferase 3-like, Dnmt3l

• Tested Applications:

  WB

• Physical Properties:

  Liquid