TXNIP Antibody

• Background:

  Thioredoxin-interacting protein (TXNIP) belongs to the arrestin family and plays a critical role in the antioxidant defense mechanisms of hematopoietic cells by activating the p53 pathway during oxidative stress (1,2) . It functions as a transcriptional repressor and acts as an oxidative stress mediator by inhibiting thioredoxin activity (2) . TXNIP expression is reduced in many types of tumors, and TXNIP overexpression inhibits tumor growth by blocking cell-cycle progression (3) . It has recently reported that TXNIP deficiency correlates with a high incidence of hepatocellular carcinoma (HCC) (4) . TXNIP and p53 interactions could potentially be a therapeutic target for oxidative stress-related diseases such as hematopoietic malignancies and metabolic diseases (5) .

• NCBI Gene ID:

  10628

• Swiss Prot:

  Q9H3M7

• Accession Number:

  NP_006463

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  TXNIP antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1285 - C2C12 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig: (94%)

• Buffer:

  TXNIP antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TXNIP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  TXNIP antibody is human, mouse and rat reactive.

• Symbol:

  TXNIP

• NCBI Official Name:

  Thioredoxin interacting protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chen KS and DeLuca HF. Isolation and characterization of a novel cDNA from HL-60 cells treated with 1, 25-dihydroxyvitamin D-3. Biochim. Biophys. Acta. 1994; 1219:26-32.

• Background Reference 02:

  Jeong M, Piao ZH, Kim MS, et al. Thioredoxin-interacting protein regulates hematopoietic stem cell quiescence and mobilization under stress conditions. J. Immunol. 2009; 183:2495–505.

• Background Reference 03:

  Han SH, Jeon JH, Ju HR, et al. VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. Oncogene 2003; 22:4035–46.

• Background Reference 04:

  Kwon HJ, Won YS, Yoon YD, et al. Vitamin D3 up-regulated protein 1 deficiency accelerates liver regeneration after partial hepatectomy in mice. J. Hepatol. 2011; 54:1168–76.

• Other Product Names:

  Thioredoxin-interacting protein, BMP and activin membrane-bound inhibitor homolog, non-metastatic gene A protein, NMA

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  171184421

• Physical Properties:

  Liquid