TXNIP Antibody

CAT: 0223-7941-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7941-01Size:0.02 mg
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Background
Thioredoxin-interacting protein (TXNIP) belongs to the arrestin family and plays a critical role in the antioxidant defense mechanisms of hematopoietic cells by activating the p53 pathway during oxidative stress (1,2) . It functions as a transcriptional repressor and acts as an oxidative stress mediator by inhibiting thioredoxin activity (2) . TXNIP expression is reduced in many types of tumors, and TXNIP overexpression inhibits tumor growth by blocking cell-cycle progression (3) . It has recently reported that TXNIP deficiency correlates with a high incidence of hepatocellular carcinoma (HCC) (4) . TXNIP and p53 interactions could potentially be a therapeutic target for oxidative stress-related diseases such as hematopoietic malignancies and metabolic diseases (5) .
NCBI Gene ID
10628
Swiss Prot
Q9H3M7
Accession Number
NP_006463
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
TXNIP antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1285 - C2C12 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Pig: (94%)
Buffer
TXNIP antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TXNIP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
TXNIP antibody is human, mouse and rat reactive.
Symbol
TXNIP
NCBI Official Name
Thioredoxin interacting protein
NCBI Organism
Homo sapiens
Background Reference 01
Chen KS and DeLuca HF. Isolation and characterization of a novel cDNA from HL-60 cells treated with 1, 25-dihydroxyvitamin D-3. Biochim. Biophys. Acta. 1994; 1219:26-32.
Background Reference 02
Jeong M, Piao ZH, Kim MS, et al. Thioredoxin-interacting protein regulates hematopoietic stem cell quiescence and mobilization under stress conditions. J. Immunol. 2009; 183:2495–505.
Background Reference 03
Han SH, Jeon JH, Ju HR, et al. VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. Oncogene 2003; 22:4035–46.
Background Reference 04
Kwon HJ, Won YS, Yoon YD, et al. Vitamin D3 up-regulated protein 1 deficiency accelerates liver regeneration after partial hepatectomy in mice. J. Hepatol. 2011; 54:1168–76.
Other Product Names
Thioredoxin-interacting protein, BMP and activin membrane-bound inhibitor homolog, non-metastatic gene A protein, NMA
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
171184421
Physical Properties
Liquid

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