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CCNDBP1 Antibody

CAT: 0223-60-533Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-533Size:400 µL
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Background
This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq].
NCBI Gene ID
23582
Swiss Prot
O95273
Accession Number
O95273
Host
Rabbit
Reactivity
Human
Immunogen
This CCNDBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-49 amino acids from the N-terminal region of human CCNDBP1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
40 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CCNDBP1
NCBI Official Name
Cyclin-D1-binding protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Lee, I., et al. Cancer Res. 70 (11) :4357-4365 (2010)
Background Reference 02
Seto, A., et al. Acta Crystallogr. Sect.Struct. Biol. Cryst. Commun. 65 (PT 1), 21-24 (2009) :
Background Reference 03
Ikushima, H., et al. EMBO J. 27 (22) :2955-2965 (2008)
Background Reference 04
Chen, W.C., et al. Histopathology 53 (5) :554-560 (2008)
Other Product Names
Cyclin-D1-binding protein 1, Grap2 and cyclin-D-interacting protein, Human homolog of Maid, CCNDBP1, DIP1, GCIP, HHM
Tested Applications
WB
Physical Properties
Liquid

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