SMPD3 Antibody

• Background:

  SMPD3 catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.

• NCBI Gene ID:

  55512

• Swiss Prot:

  Q9NY59

• Accession Number:

  Q9NY59

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SMPD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-165 amino acids from the N-terminal region of human SMPD3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  71 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SMPD3

• NCBI Official Name:

  Sphingomyelin phosphodiesterase 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Filosto, S., et al. J. Biol. Chem. 285 (14) :10213-10222 (2010)

• Background Reference 03:

  Maupas-Schwalm, F., et al. Cell. Signal. 21 (12) :1925-1934 (2009)

• Background Reference 04:

  Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

• Other Product Names:

  Sphingomyelin phosphodiesterase 3, Neutral sphingomyelinase 2, nSMase-2, nSMase2, Neutral sphingomyelinase II, SMPD3

• Tested Applications:

  WB

• Protein ID:

  73921262

• Physical Properties:

  Liquid