SMPD1 Antibody

• Background:

  SMPD1 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB) .

• NCBI Gene ID:

  6609

• Swiss Prot:

  P17405

• Accession Number:

  NP_000534

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SMPD1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Membrane, Cancer, Signal Transduction, Neuroscience

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. XBL-10407 - Fetal Heart Tissue Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SMPD1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  65 kDa

• Applications Notes:

  SMPD1 antibody can be used for detection of SMPD1 by ELISA at 1:62500. SMPD1 antibody can be used for detection of SMPD1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  SMPD1

• NCBI Official Name:

  Sphingomyelin phosphodiesterase 1, acid lysosomal

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zeidan, Y.H., (2008) J. Cell Biol. 181 (2), 335-350.

• Other Product Names:

  SMPD1, ASM, NPD, ASMASE

• Tested Applications:

  ELISA, WB

• Protein ID:

  56117840

• Physical Properties:

  Liquid