SMPD1 Antibody

• Background :

  SMPD1 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB) .

• NCBI Gene ID :

  6609

• Swiss Prot :

  P17405

• Accession Number :

  NP_000534

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SMPD1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Membrane, Cancer, Signal Transduction, Neuroscience

• Purification :

  Antibody is purified by peptide affinity chromatography method.

• Positive Control :

  Cat. No. XBL-10407 - Fetal Heart Tissue Lysate

• Concentration :

  Batch dependent

• Buffer :

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SMPD1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight :

  65 kDa

• Applications Notes :

  SMPD1 antibody can be used for detection of SMPD1 by ELISA at 1:62500. SMPD1 antibody can be used for detection of SMPD1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol :

  SMPD1

• NCBI Official Name :

  Sphingomyelin phosphodiesterase 1, acid lysosomal

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Zeidan, Y.H., (2008) J. Cell Biol. 181 (2), 335-350.

• Other Product Names :

  SMPD1, ASM, NPD, ASMASE

• Tested Applications :

  ELISA, WB

• Protein ID :

  56117840

• Physical Properties :

  Liquid