SMPD1 / ASM Antibody

• Background:

  The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB) . Multiple transcript variants encoding different isoforms have been identified.

• NCBI Gene ID:

  6609

• Swiss Prot:

  P17405

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein of human SMPD1 / ASM

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer, Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  THP-1

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 60kDa

• Fragment:

  IgG

• Symbol:

  SMPD1

• Positive Control 2:

  HepG2

• Positive Control 3:

  U-251MG

• Positive Control 4:

  MCF-7

• Positive Control 5:

  Mouse brain

• Positive Control 6:

  Mouse liver

• NCBI Official Name:

  Sphingomyelin phosphodiesterase 1, acid lysosomal

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  SMPD1, ASM, NPD, ASMASE

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid