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Mouse Wee1 Antibody

CAT: 0223-60-265Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-265Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Wee1 may act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (By similarity) .
NCBI Gene ID
22390
Swiss Prot
P47810
Accession Number
P47810
Host
Rabbit
Reactivity
Human
Immunogen
This Mouse Wee1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-230 amino acids from the Central region of mouse Wee1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
72 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Wee1
NCBI Official Name
Wee1-like protein kinase
NCBI Organism
Mus musculus
Background Reference 01
Muller, M., et al. J. Cell. Sci. 123 (PT 2), 286-294 (2010) :
Background Reference 02
Kim, M.J., et al. Oncol. Rep. 19 (5) :1323-1329 (2008)
Background Reference 03
Tanaka, Y., et al. Biochem. Biophys. Res. Commun. 352 (1) :21-28 (2007)
Background Reference 04
Tominaga, Y., et al. Int. J. Biol. Sci. 2 (4) :161-170 (2006)
Other Product Names
Wee1-like protein kinase, Wee1A kinase, Wee1
Tested Applications
WB
Physical Properties
Liquid

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