ITPK1 Antibody

• Background:

  Kinase that can phosphorylate various inositol polyphosphate such as Ins (3,4,5,6) P4 or Ins (1,3,4) P3. Phosphorylates Ins (3,4,5,6) P4 at position 1 to form Ins (1,3,4,5,6) P5. This reaction is thought to have regulatory importance, since Ins (3,4,5,6) P4 is an inhibitor of plasma membrane Ca (2+) -activated Cl (-) channels, while Ins (1,3,4,5,6) P5 is not. Also phosphorylates Ins (1,3,4) P3 on O-5 and O-6 to form Ins (1,3,4,6) P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins (1,3,4,5) P4 and Ins (1,3,4,6) P4 to Ins (1,3,4) P3, and Ins (1,3,4,5,6) P5 to Ins (3,4,5,6) P4. May also act as an isomerase that interconverts the inositol tetraphosphate isomers Ins (1,3,4,5) P4 and Ins (1,3,4,6) P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.

• NCBI Gene ID:

  3705

• Swiss Prot:

  Q13572

• Accession Number:

  Q13572

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ITPK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-54 amino acids from the N-terminal region of human ITPK1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  46 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ITPK1

• NCBI Official Name:

  Inositol-tetrakisphosphate 1-kinase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 02:

  Yoshida, T., et al. Int. J. Mol. Med. 25 (4) :649-656 (2010)

• Background Reference 03:

  Oguri, M., et al. Am. J. Hypertens. 23 (1) :70-77 (2010)

• Background Reference 04:

  Yoshida, T., et al. Int. J. Mol. Med. 24 (4) :539-547 (2009)

• Other Product Names:

  Inositol-tetrakisphosphate 1-kinase, Inositol 1,4-trisphosphate 5/6-kinase, Inositol-triphosphate 5/6-kinase, Ins (1,4) P (3) 5/6-kinase, ITPK1

• Tested Applications:

  WB

• Protein ID:

  83288249

• Physical Properties:

  Liquid