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ITPKA Antibody

CAT: 0223-63-441Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-441Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ITPKA regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins (1,3,4,5) P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. ITPKA and ITPKB are 68% identical in the C-terminus region.
NCBI Gene ID
3706
Swiss Prot
P23677
Accession Number
P23677
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This ITPKA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-375 amino acids from the C-terminal region of human ITPKA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
51 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ITPKA
NCBI Official Name
Inositol-trisphosphate 3-kinase A
NCBI Organism
Homo sapiens
Background Reference 01
Gonzalez, B., et al., Mol. Cell 15 (5) :689-701 (2004) .
Background Reference 02
Mishra, J., et al., Biophys. J. 83 (3) :1298-1316 (2002) .
Background Reference 03
Schell, M.J., et al., J. Biol. Chem. 276 (40) :37537-37546 (2001) .
Background Reference 04
Communi, D., et al., EMBO J. 16 (8) :1943-1952 (1997) .
Other Product Names
Inositol-trisphosphate 3-kinase A, Inositol 1,5-trisphosphate 3-kinase A, IP3 3-kinase A, IP3K A, InsP 3-kinase A, ITPKA
Tested Applications
WB
Protein ID
124807
Physical Properties
Liquid

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