ITPKA Antibody

• Background:

  ITPKA regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins (1,3,4,5) P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. ITPKA and ITPKB are 68% identical in the C-terminus region.

• NCBI Gene ID:

  3706

• Swiss Prot:

  P23677

• Accession Number:

  P23677

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This ITPKA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-375 amino acids from the C-terminal region of human ITPKA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  51 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ITPKA

• NCBI Official Name:

  Inositol-trisphosphate 3-kinase A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gonzalez, B., et al., Mol. Cell 15 (5) :689-701 (2004) .

• Background Reference 02:

  Mishra, J., et al., Biophys. J. 83 (3) :1298-1316 (2002) .

• Background Reference 03:

  Schell, M.J., et al., J. Biol. Chem. 276 (40) :37537-37546 (2001) .

• Background Reference 04:

  Communi, D., et al., EMBO J. 16 (8) :1943-1952 (1997) .

• Other Product Names:

  Inositol-trisphosphate 3-kinase A, Inositol 1,5-trisphosphate 3-kinase A, IP3 3-kinase A, IP3K A, InsP 3-kinase A, ITPKA

• Tested Applications:

  WB

• Protein ID:

  124807

• Physical Properties:

  Liquid