STAT3 Antibody

• Background:

  STAT3 Antibody: STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6), STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT3 signals are pivotal to the proliferation and differentiation of neural stem cells and also participate in neuronal regeneration and cancers of the nervous system.

• NCBI Gene ID:

  6774

• Swiss Prot:

  P40763

• Accession Number:

  NP_644805

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  STAT3 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1308 - Human Small Intestine Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (100%), Pig: (100%), Chicken: (100%)

• Buffer:

  STAT3 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  STAT3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Calculated Molecular Weight:

  Predicted: 85 kDa

• Fragment:

  IgG

• Symbol:

  STAT3

• Positive Control 2:

  Cat. No. 11-801 - Human Small Intestine Tissue Slide

• NCBI Official Name:

  Signal transducer and activator of transcription 3 (acute-phase response factor)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Schaefer TS, Sanders LK, and Nathans D. Cooperative transcriptional activity of Jun and Stat3b, a short form of Stat3. Proc. Natl. Acad. Sci. USA 1995; 92:9097-101.

• Background Reference 02:

  Leonard WJ and O'Shea JJ. Jaks and STATs: biological implications. Annu. Rev. Immunol. 1998; 16:293-322.

• Background Reference 03:

  Schindler C and Darnell JE Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 1995; 64:621-51.

• Background Reference 04:

  Rajan P. STATus and context within the mammalian nervous system. Mol. Med. 2011; 17:965-73

• Other Product Names:

  STAT3 Antibody: APRF, HIES, APRF, Signal transducer and activator of transcription 3, Acute-phase response factor

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  21618340

• Physical Properties:

  Liquid