STAT4 Antibody

• Background:

  The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.

• NCBI Gene ID:

  6775

• Swiss Prot:

  Q14765

• Accession Number:

  Q14765

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This STAT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 666-695 amino acids from the C-terminal region of human STAT4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  86 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  STAT4

• NCBI Official Name:

  Signal transducer and activator of transcription 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Plant, D., et al. Ann. Rheum. Dis. 69 (8) :1548-1553 (2010)

• Background Reference 02:

  Gestermann, N., et al. Genes Immun. 11 (5) :432-438 (2010)

• Background Reference 03:

  Schuurhof, A., et al. Pediatr. Pulmonol. 45 (6) :608-613 (2010)

• Background Reference 04:

  Vuong, M.T., et al. PLoS ONE (5), E10559 (2010) :

• Other Product Names:

  Signal transducer and activator of transcription 4, STAT4

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  6226158

• Physical Properties:

  Liquid