STAM2 Antibody

• Background:

  The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM) . Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.

• NCBI Gene ID:

  10254

• Swiss Prot:

  O75886

• Accession Number:

  O75886

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This STAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-172 amino acids from the Central region of human STAM2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  58 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  STAM2

• NCBI Official Name:

  Signal transducing adapter molecule 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Stuible, M., et al. J. Biol. Chem. 285 (31) :23899-23907 (2010)

• Background Reference 02:

  Rismanchi, N., et al. Traffic 10 (2) :201-217 (2009)

• Background Reference 03:

  Venkatesan, K., et al. Nat. Methods 6 (1) :83-90 (2009)

• Background Reference 04:

  Kong, C., et al. J. Biol. Chem. 282 (20) :15294-15301 (2007)

• Other Product Names:

  Signal transducing adapter molecule 2, STAM-2, Hrs-binding protein, STAM2, HBP

• Tested Applications:

  WB

• Physical Properties:

  Liquid