PDE8A Antibody

• Background:

  PDE8A plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase, which has a high affinity for cAMP, may be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.

• NCBI Gene ID:

  5151

• Swiss Prot:

  O60658

• Accession Number:

  O60658

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PDE8A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 557-587 amino acids from the Central region of human PDE8A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  93 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PDE8A

• NCBI Official Name:

  High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wu, P., Proc. Natl. Acad. Sci. U.S.A. 101 (51), 17634-17639 (2004)

• Background Reference 02:

  Gamanuma, M., Cell. Signal. 15 (6), 565-574 (2003)

• Other Product Names:

  High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, PDE8A

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid