PDE6A Antibody

• Background:

  This gene encodes the cyclic-GMP (cGMP) -specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

• NCBI Gene ID:

  5145

• Swiss Prot:

  P16499

• Accession Number:

  P16499

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PDE6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDE6A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  100 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PDE6A

• NCBI Official Name:

  Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Clark, G.R., et al. Ophthalmology 117 (11) :2169-2177 (2010)

• Background Reference 02:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 03:

  Perlis, R.H., et al. Biol. Psychiatry 67 (11) :1110-1113 (2010)

• Background Reference 04:

  Bazhin, A.V., et al. Cell. Mol. Life Sci. 67 (5) :817-828 (2010)

• Other Product Names:

  Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, GMP-PDE alpha, PDE V-B1, PDE6A, PDEA

• Tested Applications:

  WB

• Protein ID:

  215274230

• Physical Properties:

  Liquid