PDE6A Antibody

CAT: 0223-56-928Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-928Size:400 µL
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Background
This gene encodes the cyclic-GMP (cGMP) -specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
NCBI Gene ID
5145
Swiss Prot
P16499
Accession Number
P16499
Host
Rabbit
Reactivity
Human
Immunogen
This PDE6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDE6A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
100 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PDE6A
NCBI Official Name
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
NCBI Organism
Homo sapiens
Background Reference 01
Clark, G.R., et al. Ophthalmology 117 (11) :2169-2177 (2010)
Background Reference 02
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 03
Perlis, R.H., et al. Biol. Psychiatry 67 (11) :1110-1113 (2010)
Background Reference 04
Bazhin, A.V., et al. Cell. Mol. Life Sci. 67 (5) :817-828 (2010)
Other Product Names
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, GMP-PDE alpha, PDE V-B1, PDE6A, PDEA
Tested Applications
WB
Protein ID
215274230
Physical Properties
Liquid

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