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MDM4 Antibody

CAT: 0223-57-314Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-314Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Two transcript variants, one protein-coding and the other likely not to be protein-coding, have been found for this gene.
NCBI Gene ID
4194
Swiss Prot
O15151
Accession Number
O15151
Host
Rabbit
Reactivity
Human
Immunogen
This MDM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human MDM4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
55 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MDM4
NCBI Official Name
Protein Mdm4
NCBI Organism
Homo sapiens
Background Reference 01
Xu, N., et al. Biochem. Biophys. Res. Commun. 401 (3) :417-421 (2010)
Background Reference 02
Sarkari, F., et al. J. Mol. Biol. 402 (5) :825-837 (2010)
Background Reference 03
Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)
Background Reference 04
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Other Product Names
Protein Mdm4, Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4, MDM4, MDMX
Tested Applications
WB
Physical Properties
Liquid

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