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CTSK Antibody

CAT: 0223-56-715Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-715Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq].
NCBI Gene ID
1513
Swiss Prot
P43235
Accession Number
P43235
Host
Rabbit
Reactivity
Human
Immunogen
This CTSK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-126 amino acids from the Central region of human CTSK.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology, Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
37 kDa
Fragment
Rabbit Ig
Symbol
CTSK
NCBI Official Name
Cathepsin K
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Novinec, M., et al. Biochem. J. 429 (2) :379-389 (2010)
Background Reference 03
Khan, B., et al. J. Investig. Med. 58 (5) :720-724 (2010)
Background Reference 04
Johnatty, S.E., et al. PLoS Genet. (7), E1001016 (2010) :
Other Product Names
Cathepsin K, Cathepsin O, Cathepsin O2, Cathepsin X, CTSK, CTSO, CTSO2
Tested Applications
WB, IHC-P, Flow
Protein ID
1168793
Physical Properties
Liquid

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