CTSF Antibody

• Background:

  Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF is a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway.

• NCBI Gene ID:

  8722

• Swiss Prot:

  Q9UBX1

• Accession Number:

  Q9UBX1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CTSF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-290 amino acids from the Central region of human CTSF.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  53 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CTSF

• NCBI Official Name:

  Cathepsin F

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kaakinen, R., Atherosclerosis 192 (2), 323-327 (2007)

• Background Reference 02:

  Oorni, K., J. Biol. Chem. 279 (33), 34776-34784 (2004)

• Other Product Names:

  Cathepsin F, CATSF, CTSF

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  12643325

• Physical Properties:

  Liquid