CTSB Antibody

• Background :

  This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP) . Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified.

• NCBI Gene ID :

  1508

• Swiss Prot :

  P07858

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human CTSB (NP_001899.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Apoptosis, Cancer, Cell Cycle, Neuroscience, Signal Transduction

• Purification :

  Affinity purification

• Positive Control :

  A375

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 24kDa/27kDa/44kDa

• Fragment :

  IgG

• Symbol :

  CTSB

• Positive Control 2 :

  HepG2

• Positive Control 3 :

  HT-1080

• Positive Control 4 :

  MCF7

• Positive Control 5 :

  A-549

• Positive Control 6 :

  Mouse liver

• NCBI Official Name :

  Cathepsin B

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  Cathepsin B, APP secretase, APPS, Cathepsin B1, Cathepsin B light chain, Cathepsin B heavy chain, CTSB, CPSB

• Tested Applications :

  WB, IHC, IF

• Physical Properties :

  Liquid