DNMT3B Antibody

• Background:

  CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

• NCBI Gene ID:

  1789

• Swiss Prot:

  Q9UBC3

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein of human DNMT3B

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  HeLa

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 120kDa

• Fragment:

  IgG

• Symbol:

  DNMT3B

• Positive Control 2:

  MCF7

• Positive Control 3:

  A-431

• Positive Control 4:

  SKOV3

• Positive Control 5:

  NIH/3T3

• Positive Control 6:

  Mouse brain

• NCBI Official Name:

  DNA (cytosine-5) -methyltransferase 3B

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  DNA (cytosine-5) -methyltransferase 3B, Dnmt3b, DNA methyltransferase HsaIIIB, DNA MTase HsaIIIB, MHsaIIIB, DNMT3B

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid