Retinoblastoma / Rb Antibody [RB1/1754]

• Background:

  Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It reacts with the hyper-phosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

• NCBI Gene ID:

  5925

• Swiss Prot:

  P06400

• Host:

  Mouse

• Reactivity:

  Human, Mouse

• Immunogen:

  A human recombinant protein was used as the immunogen for this Rb antibody.

• Clonality:

  Monoclonal

• Clone:

  RB1/1754

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1, kappa

• Symbol:

  RB1

• NCBI Official Name:

  Retinoblastoma 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110, RB1

• Tested Applications:

  WB, IP, IHC-P

• Physical Properties:

  Liquid