RB1 Antibody

• Background:

  The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

• NCBI Gene ID:

  5925

• Swiss Prot:

  P06400

• Host:

  Rabbit

• Reactivity:

  Human, Rat

• Immunogen:

  Recombinant protein of human RB1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Transcription

• Purification:

  Affinity purification

• Positive Control:

  Jurkat

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 110kDa

• Fragment:

  IgG

• Symbol:

  RB1

• NCBI Official Name:

  Retinoblastoma 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  RB1, RB, pRb, OSRC, pp110, p105-Rb

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid